Article
Clonal dynamics in early human embryogenesis inferred from somatic mutation.
Nature - 1 Sept 2021
Park Seongyeol, Mali Nanda Maya, Kim Ryul, Choi Jeong-Woo, Lee Junehawk, Lim Joonoh, Park Jung Min, Park Jung Woo, Kim Donghyun, Kim Taewoo, Yi Kijong, Choi June Hyug, Kwon Seong Gyu, Hong Joo Hee, Youk Jeonghwan, An Yohan, Kim Su Yeon, Oh Soo A, Kwon Youngoh, Hong Dongwan, Kim Moonkyu, Kim Dong Sun, Park Ji Young, Oh Ji Won, Ju Young Seok
Abstract excerpt
Cellular dynamics and fate decision in early human embryogenesis remain largely unknown owing to the challenges of performing studies in human embryos1. Here, we explored whole-genomes of 334 single-cell colonies and targeted deep sequences of 379 bulk tissues obtained from various anatomical locations of seven recently deceased adult human donors. Using somatic mutations as an intrinsic barcode, we reconstructed...
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