Article
Extensive phylogenies of human development inferred from somatic mutations.
Nature - 1 Sept 2021
Coorens Tim H H, Moore Luiza, Robinson Philip S, Sanghvi Rashesh, Christopher Joseph, Hewinson James, Przybilla Moritz J, Lawson Andrew R J, Spencer Chapman Michael, Cagan Alex, Oliver Thomas R W, Neville Matthew D C, Hooks Yvette, Noorani Ayesha, Mitchell Thomas J, Fitzgerald Rebecca C, Campbell Peter J, Martincorena Iñigo, Rahbari Raheleh, Stratton Michael R
Abstract excerpt
Starting from the zygote, all cells in the human body continuously acquire mutations. Mutations shared between different cells imply a common progenitor and are thus naturally occurring markers for lineage tracing1,2. Here we reconstruct extensive phylogenies of normal tissues from three adult individuals using whole-genome sequencing of 511 laser capture microdissections. Reconstructed embryonic progenitors in...
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