Article
Somatic mutations reveal asymmetric cellular dynamics in the early human embryo.
Nature - 30 Mar 2017
Ju Young Seok, Martincorena Inigo, Gerstung Moritz, Petljak Mia, Alexandrov Ludmil B, Rahbari Raheleh, Wedge David C, Davies Helen R, Ramakrishna Manasa, Fullam Anthony, Martin Sancha, Alder Christopher, Patel Nikita, Gamble Steve, O'Meara Sarah, Giri Dilip D, Sauer Torril, Pinder Sarah E, Purdie Colin A, Borg Åke, Stunnenberg Henk, van de Vijver Marc, Tan Benita K T, Caldas Carlos, Tutt Andrew, Ueno Naoto T, van 't Veer Laura J, Martens John W M, Sotiriou Christos, Knappskog Stian, Span Paul N, Lakhani Sunil R, Eyfjörd Jórunn Erla, Børresen-Dale Anne-Lise, Richardson Andrea, Thompson Alastair M, Viari Alain, Hurles Matthew E, Nik-Zainal Serena, Campbell Peter J, Stratton Michael R
Abstract excerpt
Somatic cells acquire mutations throughout the course of an individual's life. Mutations occurring early in embryogenesis are often present in a substantial proportion of, but not all, cells in postnatal humans and thus have particular characteristics and effects. Depending on their location in the genome and the proportion of cells they are present in, these mosaic mutations can cause a wide range of genetic...
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