Article
Lineage tracing of normal human development and childhood cancers
2020-01-01
Abstract excerpt
From fertilisation onwards, the cells of the human body continuously experience damage to their genome, either from intrinsic causes or from exposure to mutagens. While the vast majority of DNA damage is repaired and the genome is replicated with extremely high fidelity, cells steadily acquire single nucleotide variants throughout life. Since cells pass these genetic changes on to their descendants, mutations shar...
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Identifiers and source
- Literature Corpus work
- ad96589f-6873-50d3-83dc-45c0559762c4
- DOI
- 10.17863/cam.72811