Article

Transgenerational transmission of post-zygotic mutations suggests symmetric contribution of first two blastomeres to human germline

2024-06-22

Abstract excerpt

Little is known about the origin of germ cells in humans. We previously leveraged post-zygotic mutations to reconstruct zygote-rooted cell lineage ancestry trees in a phenotypically normal woman, termed NC0. Here, by sequencing the genome of her children and their father, we analyzed the transmission of early pre-gastrulation lineages and corresponding mutations across human generations. We found that the germline...

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Literature Corpus work: 60399a6f-ef5c-5691-baec-f7dbd6277218
DOI: 10.1101/2024.06.18.599438

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