Article
Phylogenetic reconstruction of adult blood cancer reveals early origins and lifelong evolution.
2020-11-12
Abstract excerpt
<title>Abstract</title> <p>Mutations in cancer-associated genes drive tumour outgrowth. However, the timing of driver mutations and dynamics of clonal expansion that lead to human cancers are largely unknown. We used 448,553 somatic mutations from whole-genome sequencing of 843 clonal haematopoietic colonies to reconstruct the phylogeny of haematopoiesis, from embryogenesis to clinical disease, in 10 patients wit...
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Identifiers and source
- Literature Corpus work
- d09c82ac-2790-54d2-9609-c6a27ec02a5f
- DOI
- 10.21203/rs.3.rs-93830/v1