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Exploiting somatic mutations to decipher human blood production: a natural lineage-tracing strategy.

Experimental hematology - 1 May 2023

Bloom Mackenzie, Malouf Camille, Rodriguez-Fraticelli Alejo, Wilkinson Adam C, Sankaran Vijay G, Cvejic Ana

Abstract excerpt

Lineage tracing using fluorescent proteins, genetic barcodes, and various other strategies has provided critical insights into the dynamics of both fetal and adult hematopoiesis in model organisms. However, these technologies cannot be readily used to study hematopoiesis in human beings. Therefore, there is a critical need to develop strategies to assess cellular dynamics within human hematopoietic tissues in...

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PMID: 36736573
DOI: 10.1016/j.exphem.2023.01.005

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