Article

Pre-mRNA Splicing Factor U2AF2 Recognizes Distinct Conformations of Nucleotide Variants at the Center of the pre-mRNA Splice Site Signal

2021-09-27

Abstract excerpt

<h4>ABSTRACT</h4> The essential pre-mRNA splicing factor U2AF2 (also called U2AF 65 ) identifies polypyrimidine (Py) tract signals of nascent transcripts, despite length and sequence variations. Previous studies have shown that the U2AF2 RNA recognition motifs (RRM1 and RRM2) preferentially bind uridine-rich RNAs. Nonetheless, the specificity of the RRM1/RRM2 interface for the central Py tract nucleotide has yet...

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Literature Corpus work: d1fdf227-f0fc-597d-90ca-d82a2c9df657
DOI: 10.1101/2021.09.27.462007

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