All-Atom Simulations Elucidate the Impact of U2AF2 Cancer-Associated Mutations on Pre-mRNA Recognition.

doi:10.1021/acs.jcim.2c00511

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Article

All-Atom Simulations Elucidate the Impact of U2AF2 Cancer-Associated Mutations on Pre-mRNA Recognition.

Journal of chemical information and modeling - 26 Dec 2022

Rozza Riccardo, Saltalamacchia Andrea, Orrico Clarissa, Janoš Pavel, Magistrato Alessandra

Abstract excerpt

The U2AF2 splicing factor, made of two tandem RNA recognition motifs (RRMs) joined by a flexible linker, selects the intronic polypyrimidine sequence of premature mRNA, thus ensuring splicing fidelity. Increasing evidence links mutations of key splicing factors, including U2AF2, to a variety of cancers. Nevertheless, the impact of U2AF2 cancer-associated mutations on polypyrimidine recognition remains unclear....

Topics

Humans
RNA Precursors
RNA Splicing
RNA-Binding Proteins
Neoplasms
Mutation
Splicing Factor U2AF

Source

Open in PubMed

Identifiers

PMID: 36040856
DOI: 10.1021/acs.jcim.2c00511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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