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Article

Recognition of the 3' splice site RNA by the U2AF heterodimer involves a dynamic population shift.

Proceedings of the National Academy of Sciences of the United States of America - 15 Nov 2016

Voith von Voithenberg Lena, Sánchez-Rico Carolina, Kang Hyun-Seo, Madl Tobias, Zanier Katia, Barth Anders, Warner Lisa R, Sattler Michael, Lamb Don C

Abstract excerpt

An essential early step in the assembly of human spliceosomes onto pre-mRNA involves the recognition of regulatory RNA cis elements in the 3' splice site by the U2 auxiliary factor (U2AF). The large (U2AF65) and small (U2AF35) subunits of the U2AF heterodimer contact the polypyrimidine tract (Py-tract) and the AG-dinucleotide, respectively. The tandem RNA recognition motif domains (RRM1,2) of U2AF65 adopt...

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Identifiers

PMID: 27799531
DOI: 10.1073/pnas.1605873113
PMCID: PMC5135374

Genes

RRM1

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Source receipt: pubmed, retrieved 7 Sept 2026.

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