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Article

Elucidation of the aberrant 3' splice site selection by cancer-associated mutations on the U2AF1.

Nature communications - 21 Sept 2020

Yoshida Hisashi, Park Sam-Yong, Sakashita Gyosuke, Nariai Yuko, Kuwasako Kanako, Muto Yutaka, Urano Takeshi, Obayashi Eiji

Abstract excerpt

The accurate exclusion of introns by RNA splicing is critical for the production of mature mRNA. U2AF1 binds specifically to the 3´ splice site, which includes an essential AG dinucleotide. Even a single amino acid mutation of U2AF1 can cause serious disease such as certain cancers or myelodysplastic syndromes. Here, we describe the first crystal structures of wild-type and pathogenic mutant U2AF1 complexed with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32958768
DOI: 10.1038/s41467-020-18559-6
PMCID: PMC7505975

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Elucidation of the aberrant 3' splice site selection by cancer-associated mutations on the U2AF1.PMID 32958768Read ↗

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