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Article

Cancer-Associated Mutations Mapped on High-Resolution Structures of the U2AF2 RNA Recognition Motifs.

Biochemistry - 12 Sept 2017

Glasser Eliezra, Agrawal Anant A, Jenkins Jermaine L, Kielkopf Clara L

Abstract excerpt

Acquired point mutations of pre-mRNA splicing factors recur among cancers, leukemias, and related neoplasms. Several studies have established that somatic mutations of a U2AF1 subunit, which normally recognizes 3' splice site junctions, recur among myelodysplastic syndromes. The U2AF2 splicing factor recognizes polypyrimidine signals that precede most 3' splice sites as a heterodimer with U2AF1. In contrast with...

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Identifiers

PMID: 28850223
DOI: 10.1021/acs.biochem.7b00551
PMCID: PMC6005654

Genes

RRM1

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Cancer-Associated Mutations Mapped on High-Resolution Structures of the U2AF2 RNA Recognition Motifs.PMID 28850223Read ↗

Elucidation of the aberrant 3' splice site selection by cancer-associated mutations on the U2AF1.Semantic proximity Read ↗

Pre-mRNA Splicing Factor U2AF2 Recognizes Distinct Conformations of Nucleotide Variants at the Center of the pre-mRNA Splice Site SignalSemantic proximity Read ↗

A Splice Site-Sensing Conformational Switch in U2AF2 is Modulated by U2AF1 and its Recurrent Myelodysplasia-Associated MutationSemantic proximity Read ↗

Insights from structures of cancer-relevant pre-mRNA splicing factors.Semantic proximity Read ↗

<i>U2AF1</i> mutations alter splice site recognition in hematological malignanciesSemantic proximity Read ↗

Multi-omics profiling of U2AF1 mutants dissects pathogenic mechanisms affecting RNA granules in myeloid malignanciesSemantic proximity Read ↗

U2AF1 mutations alter splice site recognition in hematological malignancies.Semantic proximity Read ↗

A pan-cancer analysis of transcriptome changes associated with somatic mutations in U2AF1 reveals commonly altered splicing events.Semantic proximity Read ↗

A splice site-sensing conformational switch in U2AF2 is modulated by U2AF1 and its recurrent myelodysplasia-associated mutation.Semantic proximity Read ↗

Splicing factor mutations and cancer.Semantic proximity Read ↗

U2AF1 mutations alter sequence specificity of pre-mRNA binding and splicing.Semantic proximity Read ↗

All-Atom Simulations Elucidate the Impact of U2AF2 Cancer-Associated Mutations on Pre-mRNA Recognition.Semantic proximity Read ↗

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