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Article

Genomic mRNA profiling reveals compensatory mechanisms for the requirement of the essential splicing factor U2AF.

Molecular and cellular biology - 1 Feb 2011

Sridharan Vinod, Heimiller Joseph, Singh Ravinder

Abstract excerpt

The large subunit of the U2 auxiliary factor (U2AF) recognizes the polypyrimidine tract (Py-tract) located adjacent to the 3' splice site to facilitate U2 snRNP recruitment. While U2AF is considered essential for pre-mRNA splicing, its requirement for splicing on a genome-wide level has not been analyzed. Using Solexa sequencing, we performed mRNA profiling for splicing in the Schizosaccharomyces pombe U2AF(59)...

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Identifiers

PMID: 21149581
DOI: 10.1128/MCB.01000-10
PMCID: PMC3028654

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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