Article

Dynamic RNA binding and unfolding by nonsense-mediated mRNA decay factor UPF2

2024-10-28

Abstract excerpt

Nonsense-mediated mRNA decay (NMD) is an mRNA surveillance pathway involved in translational control and gene expression regulation. Core NMD factors UPF1, UPF2 and UPF3B are conserved from yeast to humans and essential to target mRNAs with a premature stop codon for decay. UPF2 binding to UPF1 activates UPF1's ATPase and helicase activities, and UPF2 binding to UPF3B is important for its association with the exon...

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Literature Corpus work: 43f65587-bf4d-5b7f-a736-b9a5e886a608
DOI: 10.1101/2024.10.26.620407

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