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Article

A splice site-sensing conformational switch in U2AF2 is modulated by U2AF1 and its recurrent myelodysplasia-associated mutation.

Nucleic acids research - 4 Jun 2020

Warnasooriya Chandani, Feeney Callen F, Laird Kholiswa M, Ermolenko Dmitri N, Kielkopf Clara L

Abstract excerpt

An essential heterodimer of the U2AF1 and U2AF2 pre-mRNA splicing factors nucleates spliceosome assembly at polypyrimidine (Py) signals preceding the major class of 3' splice sites. U2AF1 frequently acquires an S34F-encoding mutation among patients with myelodysplastic syndromes (MDS). The influence of the U2AF1 subunit and its S34F mutation on the U2AF2 conformations remains unknown. Here, we employ single...

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Identifiers

PMID: 32343311
DOI: 10.1093/nar/gkaa293
PMCID: PMC7261175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A splice site-sensing conformational switch in U2AF2 is modulated by U2AF1 and its recurrent myelodysplasia-associated mutation.PMID 32343311Read ↗

A Splice Site-Sensing Conformational Switch in U2AF2 is Modulated by U2AF1 and its Recurrent Myelodysplasia-Associated MutationSemantic proximity Read ↗

Recognition of the 3' splice site RNA by the U2AF heterodimer involves a dynamic population shift.Semantic proximity Read ↗

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