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Article

Insights from structures of cancer-relevant pre-mRNA splicing factors.

Current opinion in genetics & development - 1 Feb 2018

Kielkopf Clara L

Abstract excerpt

Pre-mRNA splicing factors recognize consensus signals within preliminary transcripts, and as cogs of the spliceosome machine, orchestrate the excision and rejoining of pre-mRNA regions for gene expression. Large-scale sequencing has demonstrated that mutations in key genes encoding pre-mRNA splicing factors are common among myeloid neoplasms and also occur in a variety of other cancers. This revelation offers new...

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Identifiers

PMID: 29128695
DOI: 10.1016/j.gde.2017.10.008
PMCID: PMC5871561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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