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Article

Mechanisms for U2AF to define 3' splice sites and regulate alternative splicing in the human genome.

Nature structural & molecular biology - 1 Nov 2014

Shao Changwei, Yang Bo, Wu Tongbin, Huang Jie, Tang Peng, Zhou Yu, Zhou Jie, Qiu Jinsong, Jiang Li, Li Hairi, Chen Geng, Sun Hui, Zhang Yi, Denise Alain, Zhang Dong-Er, Fu Xiang-Dong

Abstract excerpt

The U2AF heterodimer has been well studied for its role in defining functional 3' splice sites in pre-mRNA splicing, but many fundamental questions still remain unaddressed regarding the function of U2AF in mammalian genomes. Through genome-wide analysis of U2AF-RNA interactions, we report that U2AF has the capacity to directly define ~88% of functional 3' splice sites in the human genome, but numerous U2AF...

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PMID: 25326705
DOI: 10.1038/nsmb.2906
PMCID: PMC4429597

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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