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Article

Current allele distribution of the human longevity gene APOE in Europe can mainly be explained by ancient admixture.

Aging cell - 1 May 2023

Kolbe Daniel, da Silva Nicolas A, Dose Janina, Torres Guillermo G, Caliebe Amke, Krause-Kyora Ben, Nebel Almut

Abstract excerpt

Variation in apolipoprotein E (APOE) has been shown to have the strongest genetic effect on human longevity. The aim of this study was to unravel the evolutionary history of the three major APOE alleles in Europe by analysing ancient samples up to 12,000 years old. We detected significant allele frequency shifts between populations and over time. Our analyses indicated that selection led to large frequency...

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Identifiers

PMID: 36951219
DOI: 10.1111/acel.13819
PMCID: PMC10186601

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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