Article

APOE4 Allele Frequencies Show Dramatic Variation Across Indian Populations

2026-04-10

Abstract excerpt

The APOE ε4 allele is the strongest genetic risk factor for Alzheimer’s Disease. However, its distribution across Indian populations is poorly characterized. We analyze APOE allele frequencies in 9,524 individuals from 83 distinct populations in the GenomeIndia dataset. ε4 frequencies show large variation across populations within India, ranging from 2.7% to 36.1%, with a median of 11%. Tribal populations have h...

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Literature Corpus work: 2d74c5c0-4f98-5b8c-ba8f-1e5d8b86366d
DOI: 10.64898/2026.04.09.26350483

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