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Article

Rare and common variants in the Apolipoprotein E gene in healthy oldest old.

Neurobiology of aging - 1 Mar 2014

Tindale Lauren C, Leach Stephen, Ushey Kevin, Daley Denise, Brooks-Wilson Angela R

Abstract excerpt

Apolipoprotein E (APOE) alleles are associated with longevity in genome-wide scans, with ε4 correlated with shorter life, and ε2 with longer life, than ε3. We hypothesized that rare APOE variants with large individual effects might also contribute to long-term good health. The APOE exons and promoter were resequenced in DNA samples from 376 healthy oldest old aged ≥ 85 yrs with no self-reported history of cancer,...

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Source

Identifiers

PMID: 24126160
DOI: 10.1016/j.neurobiolaging.2013.09.010

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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