Article
Varying Effects of APOE Alleles on Extreme Longevity in European Ethnicities.
The journals of gerontology. Series A, Biological sciences and medical sciences - 13 Nov 2019
Gurinovich Anastasia, Andersen Stacy L, Puca Annibale, Atzmon Gil, Barzilai Nir, Sebastiani Paola
Abstract excerpt
APOE is a well-studied gene with multiple effects on aging and longevity. The gene has three alleles: e2, e3, and e4, whose frequencies vary by ethnicity. While the e2 is associated with healthy cognitive aging, the e4 allele is associated with Alzheimer's disease and early mortality and therefore its prevalence among people with extreme longevity (EL) is low. Using the PopCluster algorithm, we identified several...
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