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Article

SuperAging is not the inverse of common-variant Alzheimer's risk: evidence across genetic ancestries.

Alzheimer's research & therapy - 23 Jul 2026

Piras Ignazio Stefano, Capuano Ana Werneck, Maher Amanda Cook, Schafer Rhiana, Bonfitto Anna, Song Serena, Taguinod Francis, Goldstein Felicia, Roberts Angela, Okonkwo Ozioma, Martersteck Adam, Huentelman Matt J, Rogalski Emily

Abstract excerpt

BACKGROUND: As longevity increases and the population over age 65 expands, advancing age remains the most reliable predictor of cognitive decline, highlighting the need to identify biological mechanisms that support exceptional cognitive aging. We tested whether lower inherited risk of Alzheimer's disease (AD) dementia predicts SuperAger status (adults ≥ 80 years with episodic memory at least as good as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42493810
DOI: 10.1186/s13195-026-02124-2
PMCID: PMC13397696

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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