Article

3D Epigenome Evolution Underlies Divergent Gene Regulatory Programs in Primate Neural Development

2025-03-12

Abstract excerpt

The expansion of the neocortex is a hallmark of human evolution and is closely linked to neural stem cell biology. Yet, the epigenetic mechanisms driving divergent gene regulation during primate neurogenesis remain elusive. Here, we comprehensively mapped 3D genome organization, chromatin accessibility and gene expression in induced pluripotent stem cells and derived neural stem cells from human, chimpanzee, goril...

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Literature Corpus work: d182f63b-d858-52ba-9372-4bbb865bb925
DOI: 10.1101/2025.03.11.642620

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