Article

Epigenomic profiling of primate LCLs reveals the evolutionary patterns of epigenetic activities in gene regulatory architectures

2019-12-19

Abstract excerpt

<h4>Summary</h4> To gain insight into the evolution of the epigenetic regulation of gene expression in primates, we extensively profiled a new panel of human, chimpanzee, gorilla, orangutan, and macaque lymphoblastoid cell lines (LCLs), using ChIP-seq for five histone marks, ATAC-seq and RNA-seq, further complemented with WGS and WGBS. We annotated regulatory elements and integrated chromatin contact maps to defi...

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Literature Corpus work: 5d1dd98f-6922-5b53-ba77-c64fc9c8e8bf
DOI: 10.1101/2019.12.18.872531

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