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An Integrative Single-Cell Epigenomic Atlas Annotates the Regulatory Genome of the Adult Mouse Brain

2026-02-07

Abstract excerpt

<h4>SUMMARY</h4> Histone modifications underpin the cell-type-specific gene regulatory programs that drive the remarkable cellular diversity of the mammalian brain. Here, we jointly profiled four histone modifications and the transcriptome in 2.5 million nuclei from the adult mouse brain. By integrating these data with chromatin accessibility, DNA methylation, and three-dimensional genome organization, we constru...

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Literature Corpus work
c6175299-0df3-5694-839f-2df907c02925
DOI
10.64898/2026.02.07.704075
Open publication

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An Integrative Single-Cell Epigenomic Atlas Annotates the Regulatory Genome of the Adult Mouse BrainDOI 10.64898/2026.02.07.704075
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