Conserved and divergent gene regulatory programs of the mammalian neocortex.

doi:10.1038/s41586-023-06819-6

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Article

Conserved and divergent gene regulatory programs of the mammalian neocortex.

Nature - 1 Dec 2023

Zemke Nathan R, Armand Ethan J, Wang Wenliang, Lee Seoyeon, Zhou Jingtian, Li Yang Eric, Liu Hanqing, Tian Wei, Nery Joseph R, Castanon Rosa G, Bartlett Anna, Osteen Julia K, Li Daofeng, Zhuo Xiaoyu, Xu Vincent, Chang Lei, Dong Keyi, Indralingam Hannah S, Rink Jonathan A, Xie Yang, Miller Michael, Krienen Fenna M, Zhang Qiangge, Taskin Naz, Ting Jonathan, Feng Guoping, McCarroll Steven A, Callaway Edward M, Wang Ting, Lein Ed S, Behrens M Margarita, Ecker Joseph R, Ren Bing

Abstract excerpt

Divergence of cis-regulatory elements drives species-specific traits1, but how this manifests in the evolution of the neocortex at the molecular and cellular level remains unclear. Here we investigated the gene regulatory programs in the primary motor cortex of human, macaque, marmoset and mouse using single-cell multiomics assays, generating gene expression, chromatin accessibility, DNA methylome and chromosomal...

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PMID: 38092918
DOI: 10.1038/s41586-023-06819-6
PMCID: PMC10719095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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