Article

The Alzheimer risk factor CD2AP causes dysfunction of the brain vascular network

2022-07-05

Abstract excerpt

<title>Abstract</title> <p>Genetic variations in CD2-associated protein (CD2AP) predispose to Alzheimer’s disease (AD) but the underlying mechanisms remain unknown. Here, we show that a cerebrovascular loss of CD2AP in AD is associated with cognitive decline and genetic downregulation of CD2AP in brain microvessels impairs memory function in two distinct mouse models. The memory deficits are linked to reduced cer...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 27e6a0e9-00db-500d-93fb-e2023fbdf37e
DOI: 10.21203/rs.3.rs-1806158/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Alzheimer risk factor CD2AP causes dysfunction of the brain vascular networkDOI 10.21203/rs.3.rs-1806158/v1Read

The Alzheimer risk factor CD2AP causes dysfunction of the brain vascular networkSemantic proximity Read

Shared and disease-specific human brain vascular signatures in Alzheimer’s disease, frontotemporal dementia, and Huntington’s diseaseSemantic proximity Read

Dysplasia of cortical capillaries as the origin of Alzheimer’s disease: experimental evidence from APP/PS1Semantic proximity Read

Single-cell multi-region dissection of brain vasculature in Alzheimer’s DiseaseSemantic proximity Read

Cerebrovascular phenotypes in mouse models of Alzheimer's disease.Semantic proximity Read

Interplay Between Vascular Dysfunction and Neurodegenerative Pathology: New Insights into Molecular Mechanisms and ManagementSemantic proximity Read

Pioneering discovery and therapeutics at the brain-vascular-immune interface.Semantic proximity Read

Intercellular Signaling Pathways as Therapeutic Targets for Vascular Dementia RepairSemantic proximity Read

Competition between distinct ApoE alleles and mCRP for the endothelial receptor CD31 differentially regulates neurovascular inflammation and Alzheimer’s disease pathologySemantic proximity Read

Endothelial Progenitor Cells and Vascular Alterations in Alzheimer’s DiseaseSemantic proximity Read

Angiopoietin signalling is a central axis of amyloid-driven vascular dysfunction in Alzheimer’s diseaseSemantic proximity Read

Characterization of transcriptomic changes in the neurovascular unit of Alzheimiers transgenic mouse models using digital spatial profilingSemantic proximity Read