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The influences of ApoE isoforms on endothelial adherens junctions and actin cytoskeleton responding to mCRP

14 Sept 2024

Abstract excerpt

Apolipoprotein E4 (ApoE4) plays an important role responding to monomeric C-reactive protein (mCRP) via binding to CD31 leading to cerebrovascular damage and Alzheimer's disease (AD). Using phosphor-proteomic profiling, we found altered cytoskeleton proteins in the microvasculature of AD brains, including increased levels of hyperphosphorylated tau (pTau) and the actin-related protein, LIMA1. To address the...

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PMID: 39276310
DOI: 10.1007/s10456-024-09946-4

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