Article

ApoE4 Promotes Thrombosis via Endothelial Cell ApoER2 and PP2A Activation

2026-08-21

Abstract excerpt

<h4>Background: </h4> APOE4, the variant of apolipoprotein E carried by 25% of individuals, is a common genetic risk factor for cardiovascular disease (CVD). Although ApoE classically participates in lipid transport, APOE4-associated risk goes beyond impact on circulating lipids. Life-threatening CVD events including myocardial infarction and stroke are driven by atherogenesis and thrombosis. In mice ApoE4 increas...

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Literature Corpus work: fd0f9d75-8314-5eb2-9825-825a289383f0
DOI: 10.64898/2026.08.17.745317

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