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Article

APOE Genotype Modulates the Relationship of Stroke With Dementia Risk: Associations and Peripheral Clues for Biological Mechanisms.

Journal of the American Heart Association - 6 Jan 2026

Zhang Chong-Hui, Huang Liang-Yu, Feng Yu-Gong, Tan Chen-Chen, Tan Lan, Xu Wei

Abstract excerpt

BACKGROUND: Stroke and APOE ε4 are established risk factors of dementia. However, it remains unclear whether stroke interacts with APOE genotypes to influence dementia occurrence. This study aims to investigate the associations of stroke and its interaction by APOE genotypes with incident risk of dementia, with a specific focus on peripheral clues for biological mechanisms. METHODS: This prospective cohort study...

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Identifiers

PMID: 41404739
DOI: 10.1161/JAHA.125.043446
PMCID: PMC12909064

Genes

APOE
ACD
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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