Article

A Soluble Platelet-Derived Growth Factor Receptor-β Originates via Pre-mRNA Splicing in the Healthy Brain and is Differentially Regulated during Hypoxia and Aging

2023-02-04

Abstract excerpt

<h4>ABSTRACT/SUMMARY</h4> The platelet-derived growth factor-BB (PDGF-BB) pathway provides critical regulation of cerebrovascular pericytes, orchestrating their investment and retention within the brain microcirculation. Dysregulated PDGF Receptor-beta (PDGFRβ) signaling can lead to pericyte defects that compromise blood-brain barrier (BBB) integrity and cerebral perfusion, impairing neuronal activity and viabili...

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Literature Corpus work: 2e06e1df-6053-5a14-bec8-8d946dbb5466
DOI: 10.1101/2023.02.03.527005

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