Article
Monomeric C-reactive protein via endothelial CD31 for neurovascular inflammation in an ApoE genotype-dependent pattern: A risk factor for Alzheimer's disease?
Aging cell - 1 Nov 2021
Zhang Zhengrong, Na Hana, Gan Qini, Tao Qiushan, Alekseyev Yuriy, Hu Junming, Yan Zili, Yang Jack B, Tian Hua, Zhu Shenyu, Li Qiang, Rajab Ibraheem M, Blusztajn Jan Krizysztof, Wolozin Benjamin, Emili Andrew, Zhang Xiaoling, Stein Thor, Potempa Lawrence A, Qiu Wei Qiao
Abstract excerpt
In chronic peripheral inflammation, endothelia in brain capillary beds could play a role for the apolipoprotein E4 (ApoE4)-mediated risk for Alzheimer's disease (AD) risk. Using human brain tissues, here we demonstrate that the interactions of endothelial CD31 with monomeric C-reactive protein (mCRP) versus ApoE were linked with shortened neurovasculature for AD pathology and cognition. Using ApoE knock-in mice,...
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