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Article

Pioneering discovery and therapeutics at the brain-vascular-immune interface.

Cell - 17 Oct 2024

Akassoglou Katerina, Davalos Dimitrios, Mendiola Andrew S, Petersen Mark A, Ryu Jae Kyu, Schachtrup Christian, Yan Zhaoqi

Abstract excerpt

The brain-vascular-immune interface has emerged as a dynamic player in brain physiology and disease. We propose integrating vascular risk factors with genetic susceptibility as the nexus for the discovery of mechanisms and therapies for neuroinflammation, neurodegeneration, and neurorepair across polygenic neurologic diseases.

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Identifiers

PMID: 39423805
DOI: 10.1016/j.cell.2024.09.018
PMCID: PMC13046387

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