Article

C/EBPβ/AEP Signaling Activated by ApoE4 and 27-Hydroxycholesterol in Macrophages Mediates Cerebral Amyloid Angiopathies in Alzheimer’s Disease

2022-05-18

Abstract excerpt

<title>Abstract</title> <p>Cerebral amyloid angiopathy (CAA), amyloid-β (Aβ) deposits in cerebral vessel walls, is commonly associated with Alzheimer’s disease (AD) and contributes to cerebrovascular dysfunctions. APOE4 is a strong genetic risk factor for both AD and CAA. However, the mechanisms underlying this genetic susceptibility remain incompletely understood. Here we show that ApoE4 and 27-hydroxycholestero...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cc1ec4c0-5da9-5999-bb3d-9072d5309a58
DOI: 10.21203/rs.3.rs-1632486/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

C/EBPβ/AEP Signaling Activated by ApoE4 and 27-Hydroxycholesterol in Macrophages Mediates Cerebral Amyloid Angiopathies in Alzheimer’s DiseaseDOI 10.21203/rs.3.rs-1632486/v1Read

Vicious circle of amyloid and leptomeningeal macrophages evokes vascular dysfunction in CAASemantic proximity Read

Deciphering the role of APOE in cerebral amyloid angiopathy: from genetic insights to therapeutic horizons.Semantic proximity Read

Cell autonomous role of border associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injurySemantic proximity Read

Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stressSemantic proximity Read

Pathways to Alzheimer’s Disease: The Intersecting Roles of Clusterin and Apolipoprotein E in Amyloid-β Regulation and Neuronal HealthSemantic proximity Read

APOE4 promotes cerebrovascular fibrosis and amyloid deposition via a pericyte-to-myofibroblast transitionSemantic proximity Read

A humanized Aβ mouse model reveals E4-dependent cognitive impairments, microglial activation, and cerebrovascular dysfunctionSemantic proximity Read

Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse modelsSemantic proximity Read

Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models.Semantic proximity Read

Cerebral amyloid angiopathy: pathogenetic mechanisms and link to dense amyloid plaquesSemantic proximity Read

Anti-amyloid immunotherapy drives APOE4 specific increases in glial reactivity, perivascular immune activation, and ARIA-like eventsSemantic proximity Read

WSB.APP/PS1 mice develop age-dependent cerebral amyloid angiopathy, cerebrovascular deficits, and white matter damage, which are modified by humanized APOE alleles.Semantic proximity Read