Article
Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies.
Nature genetics - 1 Jan 2022
Lopes Katia de Paiva, Snijders Gijsje J L, Humphrey Jack, Allan Amanda, Sneeboer Marjolein A M, Navarro Elisa, Schilder Brian M, Vialle Ricardo A, Parks Madison, Missall Roy, van Zuiden Welmoed, Gigase Frederieke A J, Kübler Raphael, van Berlekom Amber Berdenis, Hicks Emily M, Bӧttcher Chotima, Priller Josef, Kahn René S, de Witte Lot D, Raj Towfique
Abstract excerpt
Microglia have emerged as important players in brain aging and pathology. To understand how genetic risk for neurological and psychiatric disorders is related to microglial function, large transcriptome studies are essential. Here we describe the transcriptome analysis of 255 primary human microglial samples isolated at autopsy from multiple brain regions of 100 individuals. We performed systematic analyses to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.