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Article

A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants.

Science translational medicine - 20 Dec 2017

Ryan Katie J, White Charles C, Patel Kruti, Xu Jishu, Olah Marta, Replogle Joseph M, Frangieh Michael, Cimpean Maria, Winn Phoebe, McHenry Allison, Kaskow Belinda J, Chan Gail, Cuerdon Nicole, Bennett David A, Boyd Justin D, Imitola Jaime, Elyaman Wassim, De Jager Philip L, Bradshaw Elizabeth M

Abstract excerpt

Microglia are emerging as a key cell type in neurodegenerative diseases, yet human microglia are challenging to study in vitro. We developed an in vitro cell model system composed of human monocyte-derived microglia-like (MDMi) cells that recapitulated key aspects of microglia phenotype and function. We then used this model system to perform an expression quantitative trait locus (eQTL) study examining 94 genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29263232
DOI: 10.1126/scitranslmed.aai7635
PMCID: PMC5945290

Genes

PILRB
RGS1

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