Article

Distinct effects of disease-associated TREM2 R47H/+ and T66M mutations on iPSC-derived microglia

2022-10-05

Abstract excerpt

Genetic findings have highlighted key roles for microglia in the pathology of neurodegenerative conditions such as Alzheimer’s disease (AD). Distinct mutations in the microglial protein TREM2 (triggering receptor expressed on myeloid cells 2) are associated with different forms of neurodegeneration in humans; R47H/+ mutations increase AD risk, while loss-of-function mutations such as TREM2 T66M result in more seve...

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Literature Corpus work: 9f722e16-be40-5363-94c8-93a50fa06a60
DOI: 10.1101/2022.10.05.511003

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