Article
A map of transcriptional heterogeneity and regulatory variation in human microglia
2019-12-20
Abstract excerpt
Microglia, the tissue resident macrophages of the CNS, are implicated in a broad range of neurological pathologies, from acute brain injury to dementia. Here, we profiled gene expression variation in primary human microglia isolated from 141 patients undergoing neurosurgery. Using single cell and bulk RNA sequencing, we defined distinct cellular populations of acutely in vivo -activated microglia, and characteris...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- e6385664-c8ae-5b81-9523-e3ceb3d307ed
- DOI
- 10.1101/2019.12.20.874099