Article

Enhancer connectome in primary human cells reveals target genes of disease-associated DNA elements

2017-08-26

Abstract excerpt

<h4>ABSTRACT</h4> The challenge of linking intergenic mutations to target genes has limited molecular understanding of human diseases. Here, we show that H3K27ac HiChIP generates high-resolution contact maps of active enhancers and target genes in rare primary human T cell subtypes and coronary artery smooth muscle cells. Differentiation of naïve T cells to T helper 17 cells or regulatory T cells creates subtype-...

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Literature Corpus work: d12f91b9-334d-520c-89b8-5f1a27a493fe
DOI: 10.1101/178269

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