Article
Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements.
Nature genetics - 1 Nov 2017
Mumbach Maxwell R, Satpathy Ansuman T, Boyle Evan A, Dai Chao, Gowen Benjamin G, Cho Seung Woo, Nguyen Michelle L, Rubin Adam J, Granja Jeffrey M, Kazane Katelynn R, Wei Yuning, Nguyen Trieu, Greenside Peyton G, Corces M Ryan, Tycko Josh, Simeonov Dimitre R, Suliman Nabeela, Li Rui, Xu Jin, Flynn Ryan A, Kundaje Anshul, Khavari Paul A, Marson Alexander, Corn Jacob E, Quertermous Thomas, Greenleaf William J, Chang Howard Y
Abstract excerpt
The challenge of linking intergenic mutations to target genes has limited molecular understanding of human diseases. Here we show that H3K27ac HiChIP generates high-resolution contact maps of active enhancers and target genes in rare primary human T cell subtypes and coronary artery smooth muscle cells. Differentiation of naive T cells into T helper 17 cells or regulatory T cells creates subtype-specific...
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