Article

Detailed Regulatory Interaction Map of the Human Heart Facilitates Gene Discovery for Cardiovascular Disease

2019-07-17

Abstract excerpt

<h4>Summary</h4> Most disease-associated variants identified by population based genetic studies are non-coding, which compromises finding causative genes and mechanisms. Presumably they interact through looping with nearby genes to modulate transcription. Hi-C provides the most complete and unbiased method for genome-wide identification of potential regulatory interactions, but finding chromatin loops in Hi-C da...

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Literature Corpus work: 03335989-5718-5cea-86d0-165442a918a7
DOI: 10.1101/705715

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