Article

Sera from individuals with narrowly focused influenza virus antibodies rapidly select viral escape mutations <i>in ovo</i>

2018-05-17

Abstract excerpt

Influenza viruses use distinct antibody escape mechanisms depending on the overall complexity of the antibody response that is encountered. When grown in the presence of a hemagglutinin (HA) monoclonal antibody, influenza viruses typically acquire a single HA mutation that reduces the binding of that specific monoclonal antibody. In contrast, when confronted with mixtures of HA monoclonal antibodies or polyclonal...

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Literature Corpus work: d1278d14-83eb-5004-ba25-1d32fe514380
DOI: 10.1101/324707

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