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Article

A class of antibodies that overcome a steric barrier to cross-group neutralization of influenza viruses

2023-04-04

Abstract excerpt

Antibody titers that inhibit the influenza virus hemagglutinin (HA) from engaging its receptor are the accepted correlate of protection from infection. Many potent antibodies with broad, intra-subtype specificity bind HA at the receptor binding site (RBS). One barrier to broad H1-H3 cross-subtype neutralization is an insertion (133a) between positions 133 and 134 on the rim of the H1 HA RBS. We describe here a cla...

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Identifiers and source

Literature Corpus work
88caff43-b8ca-5521-a69b-7375a981df03
DOI
10.1101/2023.04.01.535242
Open publication

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A class of antibodies that overcome a steric barrier to cross-group neutralization of influenza virusesDOI 10.1101/2023.04.01.535242
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