Article

Novel epitopes of human monoclonal antibodies targeting the influenza virus N1 neuraminidase

2021-02-27

Abstract excerpt

Influenza virus neuraminidase (NA) targeting antibodies are an independent correlate of protection against infection. Antibodies against the NA act by blocking enzymatic activity, preventing virus release and transmission. As we advance the development of improved influenza virus vaccines that incorporate standard amounts of NA antigen, it is important to identify the antigenic targets of human monoclonal antibodi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 207835c2-42cb-5f11-bdb0-bfca0effdce4
DOI: 10.1101/2021.02.26.433142

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Novel epitopes of human monoclonal antibodies targeting the influenza virus N1 neuraminidaseDOI 10.1101/2021.02.26.433142Read

Novel Epitopes of the Influenza Virus N1 Neuraminidase Targeted by Human Monoclonal Antibodies.Semantic proximity Read

Identification and Characterization of Novel Antibody Epitopes on the N2 Neuraminidase.Semantic proximity Read

Antibody Pressure by a Human Monoclonal Antibody Targeting the 2009 Pandemic H1N1 Virus Hemagglutinin Drives the Emergence of a Virus with Increased Virulence in MiceSemantic proximity Read

Monoclonal antibodies targeting the influenza virus N6 neuraminidaseSemantic proximity Read

Antigenic characterisation of human monoclonal antibodies for therapeutic use against H7N9 avian influenza virusSemantic proximity Read

Diversity of antigenic mutants of influenza A(H1N1)pdm09 virus escaped from human monoclonal antibodies.Semantic proximity Read

Human anti-N1 monoclonal antibodies elicited by pandemic H1N1 virus infection broadly inhibit HxN1 viruses in vitro and in vivoSemantic proximity Read

Influenza Human Monoclonal Antibody 1F1 Interacts with Three Major Antigenic Sites and Residues Mediating Human Receptor Specificity in H1N1 VirusesSemantic proximity Read

Complete mapping of viral escape from neutralizing antibodies.Semantic proximity Read

Identification of Amino Acid Substitutions Supporting Antigenic Change of Influenza A(H1N1)pdm09 VirusesSemantic proximity Read

Differences in the ease with which mutant viruses escape from human monoclonal antibodies against the HA stem of influenza A virus.Semantic proximity Read

A Unique and Conserved Neutralization Epitope in H5N1 Influenza Viruses Identified by an Antibody against the A/Goose/Guangdong/1/96 HemagglutininSemantic proximity Read