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Article

Hemagglutinin receptor binding avidity drives influenza A virus antigenic drift.

Science (New York, N.Y.) - 30 Oct 2009

Hensley Scott E, Das Suman R, Bailey Adam L, Schmidt Loren M, Hickman Heather D, Jayaraman Akila, Viswanathan Karthik, Raman Rahul, Sasisekharan Ram, Bennink Jack R, Yewdell Jonathan W

Abstract excerpt

Rapid antigenic evolution in the influenza A virus hemagglutinin precludes effective vaccination with existing vaccines. To understand this phenomenon, we passaged virus in mice immunized with influenza vaccine. Neutralizing antibodies selected mutants with single-amino acid hemagglutinin substitutions that increased virus binding to cell surface glycan receptors. Passaging these high-avidity binding mutants in...

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Share to Antibodies, Neutralizing
Share to Antigenic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemagglutinin Glycoproteins, Influenza Virus

Share to Influenza A Virus, H1N1 Subtype

Share to Influenza Vaccines

Share to Models, Immunological

Share to Receptors, Virus

Share to Serial Passage

Source

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Identifiers

PMID: 19900932
DOI: 10.1126/science.1178258
PMCID: PMC2784927

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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