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A new class of antibodies that overcomes a steric barrier to cross-group neutralization of influenza viruses

21 Dec 2023

Abstract excerpt

Antibody titers that inhibit the influenza virus hemagglutinin (HA) from engaging its receptor are the accepted correlate of protection from infection. Many potent antibodies with broad, intra-subtype specificity bind HA at the receptor binding site (RBS). One barrier to broad H1-H3 cross-subtype neutralization is an insertion (133a) between positions 133 and 134 on the rim of the H1 HA RBS. We describe here a...

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PMID: 38127922
DOI: 10.1371/journal.pbio.3002415

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