Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differences in the ease with which mutant viruses escape from human monoclonal antibodies against the HA stem of influenza A virus.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Nov 2018

Yamayoshi Seiya, Yasuhara Atsuhiro, Ito Mutsumi, Uraki Ryuta, Kawaoka Yoshihiro

Abstract excerpt

BACKGROUND: Broadly protective human monoclonal antibodies that recognize the conserved epitopes in the HA of influenza A virus are being developed as therapeutic agents. Emergence of resistant viruses must always be considered when developing therapeutic agents against influenza. OBJECTIVES: We examined human hetero-reactive mAbs against the HA stem of influenza A virus for the ease with which escape mutant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to Antibodies, Neutralizing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antibodies, Viral

Share to Epitopes

Share to Hemagglutinin Glycoproteins, Influenza Virus

Share to Immune Evasion

Share to Immunization, Passive

Share to Influenza A virus

Source

Open in PubMed Open full text

Identifiers

PMID: 30292135
DOI: 10.1016/j.jcv.2018.09.016
PMCID: PMC12973287

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differences in the ease with which mutant viruses escape from human monoclonal antibodies against the HA stem of influenza A virus.PMID 30292135Read ↗

Human protective monoclonal antibodies against the HA stem of group 2 HAs derived from an H3N2 virus-infected human.Semantic proximity Read ↗

A stable trimeric influenza hemagglutinin stem as a broadly protective immunogenSemantic proximity Read ↗

Convergent Evolution in Breadth of Two VH6-1-Encoded Influenza Antibody Clonotypes from a Single DonorSemantic proximity Read ↗

Novel epitopes of human monoclonal antibodies targeting the influenza virus N1 neuraminidaseSemantic proximity Read ↗

Novel Epitopes of the Influenza Virus N1 Neuraminidase Targeted by Human Monoclonal Antibodies.Semantic proximity Read ↗

A Broadly Neutralizing Human Monoclonal Antibody That Recognizes a Conserved, Novel Epitope on the Globular Head of the Influenza H1N1 Virus HemagglutininSemantic proximity Read ↗

The influenza hemagglutinin stem antibody CR9114: Evidence for a narrow evolutionary path towards universal protectionSemantic proximity Read ↗

Different genetic barriers for resistance to HA stem antibodies in influenza H3 and H1 viruses.Semantic proximity Read ↗

Diversity of antigenic mutants of influenza A(H1N1)pdm09 virus escaped from human monoclonal antibodies.Semantic proximity Read ↗

Conserved sites on the influenza H1 and H3 hemagglutinin recognized by human antibodiesSemantic proximity Read ↗

A protective and broadly binding antibody class engages the influenza virus hemagglutinin head at its stem interfaceSemantic proximity Read ↗

Resistance Mutations to Broadly Neutralizing Antibodies Destabilize Hemagglutinin and Attenuate H1N1 Influenza Virus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.