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Article

Sera from Individuals with Narrowly Focused Influenza Virus Antibodies Rapidly Select Viral Escape Mutations In Ovo.

Journal of virology - 1 Oct 2018

Davis Amy K F, McCormick Kevin, Gumina Megan E, Petrie Joshua G, Martin Emily T, Xue Katherine S, Bloom Jesse D, Monto Arnold S, Bushman Frederic D, Hensley Scott E

Abstract excerpt

Influenza viruses use distinct antibody escape mechanisms depending on the overall complexity of the antibody response that is encountered. When grown in the presence of a hemagglutinin (HA) monoclonal antibody, influenza viruses typically acquire a single HA mutation that reduces the binding of that specific monoclonal antibody. In contrast, when confronted with mixtures of HA monoclonal antibodies or polyclonal...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hemagglutinin Glycoproteins, Influenza Virus

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Share to Influenza A Virus, H1N1 Subtype

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Source

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Identifiers

PMID: 30045982
DOI: 10.1128/JVI.00859-18
PMCID: PMC6146816

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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