Article

Mapping person-to-person variation in viral mutations that escape polyclonal serum targeting influenza hemagglutinin

2019-06-13

Abstract excerpt

A longstanding question is how influenza evolves to escape human immunity, which is polyclonal and can target many distinct epitopes on the virus. Here we map how all amino-acid mutations to influenza’s major surface protein affect viral neutralization by polyclonal human sera. The serum of some individuals is so focused that it selects single mutations that reduce viral neutralization by over an order of magnitud...

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Literature Corpus work: 52ceffdf-2c02-5c3b-922a-75c0a3797d32
DOI: 10.1101/670497

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