Article
Novel Epitopes of the Influenza Virus N1 Neuraminidase Targeted by Human Monoclonal Antibodies.
Journal of virology - 11 May 2022
Kirkpatrick Roubidoux Ericka, Sano Kaori, McMahon Meagan, Carreño Juan Manuel, Capuano Christina, Jiang Kaijun, Simon Viviana, van Bakel Harm, Wilson Patrick, Krammer Florian
Abstract excerpt
Influenza virus neuraminidase (NA)-targeting antibodies are an independent correlate of protection against influenza. Antibodies against the NA act by blocking enzymatic activity, preventing virus release and transmission. As we advance the development of improved influenza virus vaccines that incorporate standard amounts of NA antigen, it is important to identify the antigenic targets of human monoclonal...
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